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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name EpCAM siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell line Y79
Methods siRNA transfection, Western blot
Expression pattern associated
Functional description Post EpCAM silencing resulted in a significant decrease (p<0.01) in the expression of the miR 17-92 cluster by 4 to eightfold in Y79 cells. We showed that the miR 17-92 cluster plays a role in RB cell proliferation and invasion.
PubMed ID 22969266
Year 2012
Title Oncogenic microRNA 17-92 cluster is regulated by epithelial cell adhesion molecule and could be a potential therapeutic target in retinoblastoma.
Drug-related ncRNA NO

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