ncRNA name | EpCAM siRNA |
ncRNA Category | siRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | human RB cell line Y79 |
Methods | siRNA transfection, Western blot |
Expression pattern | associated |
Functional description | Post EpCAM silencing resulted in a significant decrease (p<0.01) in the expression of the miR 17-92 cluster by 4 to eightfold in Y79 cells. We showed that the miR 17-92 cluster plays a role in RB cell proliferation and invasion. |
PubMed ID | 22969266 |
Year | 2012 |
Title | Oncogenic microRNA 17-92 cluster is regulated by epithelial cell adhesion molecule and could be a potential therapeutic target in retinoblastoma. |
Drug-related ncRNA | NO |
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